This antiviral compound was isolated in mycelium culture filtrate of " N . sphaerica ".
2.
Demain said that he and Phaff apparently were the first in the world to carry out affinity chromatography, using a pectic acid gel to selectively adsorb YPG from culture filtrates.
3.
This species has also been reported to produce chaetoatrosin A, a selective inhibitor of chitin synthase II . This enzyme is involved in septum formation and cellular division, and its inhibition by chaetoatrosin A is thought to be the mechanism underlying the antifungal effects of " C . atrobrunneum " culture filtrates against several medically important fungi including " Cryptococcus neoformans ".
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